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  • Radiation Oncology research

Radiation Oncology research

Alfred Health Radiation Oncology is a major service with treatment facilities at The Alfred (ARO) and LaTrobe Regional Hospital, Gippsland (GRO).

In this section

  • Radiation Oncology clinical trials

About our research

Clinical research in a radiotherapy setting looks to improve patient treatments, care and outcomes.

We do this by conducting research on new treatments, new equipment and new ways of working.

Research can be both:

  • Retrospective - looking back at data we have collected in the past
  • Prospective - collecting data from today and into the future

Much of our research involves clinical trials - comparing new treatments with current treatments in a controlled and safe manner.

Find out more about Radiation Oncology clinical trials.

Current research projects

We are currently conducting the following research projects:

  • Review of patient outcomes after total body irradiation from two large centres with different practices
  • A biochemical definition of cure following brachytherapy for prostate cancer
  • Dosimetric verification and nanoparticle dose enhancement of synchrotron microbeams
  • Development of real time source tracking systems and dosimetric verification techniques for high dose rate brachytherapy
  • LDR Brachytherapy Calibration Inter-comparison
  • Long Term Stability of a HDR Brachytherapy Well Chamber
  • Metal Artefact Reduction Algorithm Analysis 
  • Dose-response models of urethral strictures for prostate patients treated with HDR brachytherapy boost
  • Predictive Modelling for Radiotherapy Treatment Planning and Dose Escalation in Locally Advanced Prostate Cancer (Predict-PCa/RT Protocol)
  • Using deep learning with MRI scanning to improve diagnosis and management of brain tumours
  • Visualisation of the oesophagus on cone-beam computed tomography with oral contrast during radiotherapy to the chest
  • 3D printing in radiotherapy
  • Dosimetric impact of catheter displacement
  • Target coverage and organs-at-risk (OAR) doses of the left breast in female lung cancer patients treated with intensity modulated radiation therapy (IMRT) but not in deep inspiration breath hold (DIBH)
  • Exhale breath hold in liver
  • An investigation of parameters affecting grid size dependence in dose distributions

Our achievements

  • First centre in the world to have real time treatment verification imaging for high dose rate brachytherapy
  • First centre in Victoria to deliver stereotactic intracranial radiosurgery and radiotherapy treatment (ARO)
  • First centre in Asia-Pacific to receive the Novalis Certification of the stereotactic program. Received re-certification in 2020 (ARO)
  • First centre in Victoria to deliver permanent radioactive seed implants for prostate cancer (ARO) 
  • First Australian centre to employ electronic portal imaging (digital real-time imaging that replaced x-ray film) to verify treatment delivery (ARO)  
  • First Australian centre with AlignRT surface-guided imaging (ARO); with Gippsland Radiation Oncology the first regional centre to use AlignRT technology
  • First centre in Australia to enable skin mark-free set ups using SGRT (ARO/GRO)
  • Established 3D printing program for tissue equivalent accessories to aid in treatment
  • Second site in Victoria to implement Volumetric Modulated Arc Therapy (GRO)

Our partners

Monash University logo

Monash University

Latrobe Regional Hospital logo

Latrobe Regional Hospital

Monash Partners Comprehensive Cancer Consortium (MPCCC) logo

Monash Partners Comprehensive Cancer Consortium (MPCCC)

RMIT University logo

RMIT University

Publications

The Movember Prostate Cancer Landscape Analysis: an assessment of unmet research needs

Kouspou MM, Fong JE, Brew N, Hsiao STF, Davidson SL, Choyke PL, Crispino T, Jain S, Jenster GW, Knudsen BS, Millar JL, Mittmann N, Ryan CJ, Tombal B, Buzza M

(2020), Nat Rev Urol, 17(9), 499-512

DOI: 10.1038/s41585-020-0349-1

External Validation of a Predictive Model of Urethral Strictures for Prostate Patients Treated With HDR Brachytherapy Boost

Panettieri, Vanessa; Rancati, Tiziana; Onjukka, Eva; Ebert, Martin A.; Joseph, David J.; Denham, James W.; Steigler, Allison; Millar, Jeremy L.

(2020), FRONT ONCOL, 10, 910

DOI: 10.3389/fonc.2020.00910

A Monte Carlo model of synchrotron radiotherapy shows good agreement with experimental dosimetry measurements: Data from the imaging and medical beamline at the Australian Synchrotron

Day LRJ, Pellicioli P, Gagliardi F, Barnes M, Smyth LML, Butler D, Livingstone J, Stevenson AW, Lye J, Poole CM, Hausermann D, Rogers PAW, Crosbie JC

(2020), PHYS MEDICA, 77, 64-74

DOI: 10.1016/j.ejmp.2020.07.017

View all publications for Radiation Oncology research

Latest news

View all news
World first cancer treatment gives hope to Melbourne mum article image

World first cancer treatment gives hope to Melbourne mum

4 Feb 2022

A groundbreaking approach to treating stage four cancer has given new hope to some patients diagnosed with the life threatening disease.

Melbourne woman Debbie was diagnosed with primary breast cancer in 2006, and had been classified as stage four since 2008. 

  • cancer
  • patient
  • radiation therapy
Find out more
Home for Christmas: Lizzy’s Story article image

Home for Christmas: Lizzy’s Story

20 Dec 2021

When 31 year old Lizzy Maric woke up in the middle of the night in May this year feeling faint she immediately knew something wasn’t right.

  • cancer
  • patients
  • radiation therapy
Find out more
Cancer trial gives new hope to Australian patients article image

Cancer trial gives new hope to Australian patients

14 Dec 2021

An international study looking at whether high and very tightly controlled doses of radiation can cure cancers previously considered incurable is in progress at The Alfred, with the first patient completing treatment in the trial.

  • cancer
  • radiation therapy
Find out more
Head of research
Prof Jeremy Millar Director of Research, Radiation Oncology

Contact us

The Alfred
Alfred Health Radiation Oncology

South Block, Lower Ground,

55 Commercial Rd, Melbourne VIC 3004

  • Phone (03) 9076 2337
Get directions
In the community
Gippsland Radiation Oncology

Latrobe Regional Hospital,

Princes Highway, Traralgon West, VIC 3844

  • Phone (03) 5173 8770
Get directions

TrialHub

Left to Right, The Hon. Darren Chester MP, Australian Government representative and local MP, Alfred Health’s Director of Research Professor Stephen Jane, Director of TrialHub Anne Woollett, and Latrobe Regional Hospital’s Chief Executive Officer Pete

TrialHub partners with regional and remote hospitals to establish their own independent and sustainable clinical trial units to increase access to potentially life-saving treatments. 

Find out more about TrialHub
Have some feedback for us? Use our feedback process to let us know.
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