Pathology research

Alfred Health Pathology Services incorporates Laboratory Haematology, Microbiology and Clinical Biochemistry (also known as Chemical Pathology) and Anatomical Pathology. 

This year’s report focuses on Haematology. Anatomical Pathology, headed by Professor Catriona McLean, is also reported.

Laboratory Haematology is primarily a diagnostic and consultative service providing expertise in blood banking, laboratory-based general haematology, including morphology, coagulation and flow cytometry, immunology tests and diagnostic bone marrow biopsies. The unit incorporates a specialist multidisciplinary transfusion medicine team which audits transfusion safety and practice.

Research collaborations involve identifying and supplying material for various registries of the Transfusion Outcomes Research Collaborative; Australia and New Zealand Intensive Care Society’s TRANSFUSE trial; Clinical Haematology and Trauma Unit clinical trials; Australian Centre for Blood Diseases (ACBD), Australasian Leukaemia and Lymphoma Group and Nucleus Network.

Current research

  • Development of highly sensitive flow cytometric techniques for detection of small volume minimal residual disease after potentially curative therapy, particularly in multiple myeloma and acute myeloid leukaemia (AML)
  • Coagulopathy associated with mechanical circulatory assist devices and heart valve dysfunction (ACBD collaboration)
  • PTP1B expression in myeloproliferative disorders as a marker of JAK-STAT pathway dysregulation
  • Haematological and biochemical complications of dapsone therapy
  • Predicting outcome in AML: molecular testing for founder mutations
  • Blood product use in bone marrow transplant and cardiac surgery patients
  • Pre-operative optimisation of haemoglobin in orthopaedic patients to limit need for transfusion

Achievements

  • Dr Victoria Ling, Haematology RACP /RCPA Advanced Trainee, won the 2014 Victorian RACP Trainee Research Award for Excellence in Adult Medicine
  • Dr Kay Htun, Haematology RACP /RCPA Advanced Trainee, won the 2014 Alfred Hospital prize for Best Advanced Physician Trainee Project
  • Dr Mandy Davis, Haematologist and Transfusion Specialist, was awarded the WTMS (Whole Time Medical Specialist) grant of $56,000 for expansion of the BloodTrack program to improve safety of blood administration.

Acute Myeloid Leukaemia: predicting outcome

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Inappropriate pre-operative testing

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Side effects of Ventricular Assist Devices (VADs)

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Publications

Markers of A1 astrocytes stratify to molecular sub-types in sporadic Creutzfeldt-Jakob disease brain

Ugalde CL, Lewis V, Stehmann C, McLean CA, Lawson VA, Collins SJ, Hill AF

(2020), Brain Communications, 2(2), fcaa029

DOI: 10.1093/braincomms/fcaa029

Atypical Sarcoid-like Granulomatous Reactions in Lymphoma: Natural History and Effect on Management

Ramanan R, Fancourt T, Berlangieri S, Grigg A

(2020), CL LYMPH MYELOM LEUK, 20(1), e11-14

DOI: 10.1016/j.clml.2019.10.005

Revealing the Proteome of Motor Cortex Derived Extracellular Vesicles Isolated from Amyotrophic Lateral Sclerosis Human Postmortem Tissues

Vassileff N, Vella LJ, Rajapaksha H, Shambrook M, Kenari AN, McLean C, Hill AF, Cheng L

(2020), CELLS-BASEL, 9(7), 1709

DOI: 10.3390/cells9071709

View all publications for Pathology research
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